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"Boys at school don't think I'm pretty. It's the whole 'no hair' thing." - Izabella to Alex Karev
Izabella Bright was the nine-year-old patient of Alex Karev, first introduced in season one's Lionheart. During Alex's last year of residency, she was diagnosed by Alex and Arizona with Neuroblastoma, a rare childhood cancer.

Alex cared for her until her death. She died on July 16, 2009, the day of Lyla Karev's birthday. She is the namesake of Lyla's middle name, as well as the method Amelia Shepherd and Alex Karev used to save the life of Maxine Marshall.